Proteomics and Cell Biology
Being integrated into the Proteomics and Mass Spectrometry Core Facility, our research focuses on the study of system-wide protein regulation using (mostly, but not exclusively) mass spectrometry based technology. We have developed a LC-MS/MS based method for the characterization of circulating microparticles in human plasma. The idea is to offer a comprehensive diagnostic method in order to study these particles in medical research of cardiovascular and pneumological diseases. Our laboratory is furthermore equipped with a cone-and-plate apparatus setup on which adherent cells, e.g. endothelial cells, can be subjected to well-defined shear stress of different quality. The idea is to study in-vitro the molecular processes of endothelial cell biology (arteriogenesis, angiogenesis) under shear stress.