Regulation of the Cardiovascular System

Our research focuses on the regulation of the systemic and pulmonary circulation in experimental animal models and humans with particular emphasis on the role of fetal programming, epigenetic mechanisms and hypoxia in this setting. Moreover, we are interested in the potential consequences of systemic vascular dysfunction/fetal programming on the regulation of glucose homeostasis.

Research area: Vascular function

  • Clinical Research
  • Animal Models
  • Vascular Biology

Current methods used in humans:

  • FMD- flow mediated dilation
  • PWV- pulse wave velocity
  • IMT- intima media thickness
  • Echocardiography
  • Pulmonary pressure at rest  and during hypoxia and exercise
  • Euglycemic hyperinsulinemic clamp studies
Dilation setup
Fig. 1: Flow mediated dilation setup

Current Methods used in mice:

  • Invasive measurement of arterial blood pressure in conscious freely moving mice 
  • Assessment of endothelial function (in vitro)
  • Invasive measurement of pulmonary artery pressure
  • Euglycemic hyperinsulinemic clamp studies
  • Measurement of skeletal muscle blood flow during euglycemic hyperinsulinemic clamp studies
  • Measurement of glucose utilization in isolated skeletal muscle
  • In vitro fertilization
mesenteric artery endothelial function
Fig. 2: Setup for the study of mesenteric artery endothelial function in vitro in mice

 

For detailed contact information, please refer to the group page, under Group Rimoldi: Link