Proteomics and Cell Biology
Being integrated into the Proteomics and Mass Spectrometry Core Facility, our research focuses on the study of system-wide protein regulation using (mostly, but not exclusively) mass spectrometry-based technology. We have developed a LC-MS/MS based method for the characterization of circulating extracellular vesicles from human plasma. On the same line, we have established an immunopeptidomics/proteogenomics pipeline in order to identify antigenic peptides presented on the cell surface by the MHC-I complex. The idea is to offer comprehensive diagnostic methods for biomedical research in the context of leukemia, cancer, cardiovascular and pneumological disease. Our laboratory is furthermore equipped with a 96-channel liquid handling robot on which magnetic bead-based methods can be implemented. In case of interest, we could provide a cone-and-plate apparatus setup on which adherent cells, e.g. endothelial cells, can be subjected to well-defined shear stresses of different quality.
Contact
Heller Manfred, Prof. Dr. phil. nat., Group leader
Murtenstrasse 28
3008 Bern
Email: manfred.heller@unibe.ch
Phone +41 31 684 04 82